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Foam‑suppressing agents for fermentation are specifically formulated to address foam generated during the fermentation process.
Release Date:
2021-12-20
Fermentation defoamers are specially formulated for fermentation processes. They are produced through complex chemical reactions that incorporate multiple functional groups with defoaming and foam‑suppressing properties, based on defoaming and foam‑inhibition principles and technologies. These products are used to control foam in a wide range of fermentation applications, including erythromycin, kitasamycin, avermectin, gentamicin, penicillin, citric acid, lysine, yeast production, and other fermentation processes.
Fermentation defoamers are specially formulated for fermentation processes. They are produced through complex chemical reactions that incorporate multiple functional groups with defoaming and foam‑suppressing properties, based on defoaming and foam‑inhibition principles and technologies. These products are a type of defoamer and are used to control foam in various fermentation applications, including the production of erythromycin, kitasamycin, avermectin, gentamicin, penicillin, citric acid, lysine, yeast, and other fermentation processes.
In the food, biotechnology, or chemical industries, large amounts of foam are inevitably generated during fermentation. Excessive foam can lead to significant overflow, causing fermentation broth to escape through vent lines or shaft seals and increasing the risk of microbial contamination. It can also reduce the efficiency of the oxygen transfer system, thereby compromising the fermentation process. So, what causes foam formation?
1. Intensity of aeration and agitation: High aeration and vigorous stirring can increase foam formation.
2. Medium formulation and raw material composition: The medium is nutrient-rich and highly viscous, generating abundant, persistent foam that makes it difficult to start stirring in the early stages.
3. Strain, seed quality, and inoculum quantity:
(1) High-quality strains with rapid growth and efficient utilization of soluble nitrogen sources result in a lower likelihood of foam formation.
(2) Poor sterilization of the culture medium leads to the degradation of sugars and nitrogen, inhibiting microbial growth and causing the seed mycelium to autolyze, thereby generating copious foam.
Performance and efficacy of fermentation antifoaming agents:
1. Acid-resistant, alkali-resistant, and high-temperature resistant
2. Active ingredient content: 98%. pH (1% aqueous solution): 6–8.
3. It does not react with the defoaming medium and is not decomposed or degraded by it, exhibiting excellent chemical stability.
4. Effective in both cold and hot aqueous solutions, suitable for use in the food industry.
5. Excellent dispersion performance and stable physicochemical properties
Method of use for fermentation antifoaming agent:
1. Can be added to the base formulation in a single step.
2. Continuously add the reactant to the fermentation broth by dropwise addition or fed-batch feeding.
3. Dosage: When used alone, add 0.15–0.2% by volume of the formulation; when combined with 0.01–0.03% of a defoaming agent, a dosage of 0.05–0.1% is sufficient to achieve excellent defoaming performance.
(1) During use, it can be mixed with vegetable oils such as soybean oil to effectively suppress foam.
(2) The recommended addition level is 1/3 to 1/2 of the dosage used for polyether‑ and silicone‑based defoamers.
(3) Prior to use, determine an appropriate addition rate based on the characteristics of the fermentation process to help increase yield; however, excessive addition of antifoaming agents may adversely affect microbial growth.
4. It is recommended to conduct defoaming tests using a small sample of the foaming liquid under actual operating conditions and to determine the appropriate dosage of the defoamer before full-scale application.
5. When used for defoaming in food or other applications, it shall be strictly handled in accordance with relevant requirements and subjected to disinfection and sterilization prior to use.
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13770937137(Ms. Ge)
No. 5, Lingxiao Road, Lukou Subdistrict, Jiangning District, Nanjing City
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